Masters of Sex

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Article Summary: Masters of Sex is explored in a Runway Magazine feature celebrating the critically acclaimed series and the powerful performances that made it a cultural touchstone.


by Mandi Pimental

Romantic songs, sappy love stories and cinematic fairytale endings.
All of these items are the juiciest ingredients of what forms our ideas
of love as children. And while swooning over the leading man in the
most recent Nicholas Spark’s movie may inspire you to find your own
“true love”, there is much more that goes into lasting romance than the
intention of happily ever after, or a well-written script.
If you break down the nitty-gritty, not so sexy, science-driven side
of love, you can see that our brain is the one responsible for those
butterflies, more so than our heart. Before you write me off as a cynical
anti-romantic, look at the facts. I myself love, love. Who doesn’t adore
the fluttering of the butterflies or an exhilarating first kiss? And although
so much mystery lies in the beginning of a relationship, what is most
interesting is how our bodies get past the feeling of ‘like’ to ‘infatuation’,
and eventually, to love.

I Love You with My Whole… Brain.
There are primarily three sections of our brain that help us to interpret affection, to recognize
reward and feel accepted. These include the hippocampus, the medial insula and the anterior
cingulate. Other parts of our brain that contribute to how we feel within a relationship include
the pituitary gland, which regulates our hormones, the amygdala which moderates our fear
and stress levels, and the hypothalamus that produces the happy chemicals that make it
possible to “fall in love”.

The Drug that is Love.
If we break down the chemicals released into
the body, we can see how the process works.
The hypothalamus releases dopamine, and
as dopamine increases, serotonin decreases.
Which is why being “lovesick” causes loss of
appetite, improved mood or feelings of obsessive
infatuation. The body also produces a substance
known as NGF, or Nerve Growth Factor. The
higher the amount of NGF, the more intense your
feelings will be at the onset, and throughout, your
relationship. As couples move from the stages of
puppy love into a deeper connection, the oxytocin
and vasopressin take over. Stored in the pituitary
gland, these hormones, when present together in
high amounts, have been proven to contribute to
the success of long-term relationships.
Too Much of a Good Thing.

The intense feelings of falling in love is usually
short-lived. Rarely lasting longer than a year, most
people’s brains cannot sustain this euphoric feeling
because one’s brain can become overloaded in
this blissful state. As silly as that sounds, it is quite
easy to explain. When we are falling in love, activity in our frontal cortex decreases, making
us not as sharp to make wise decisions. The amygdala also shuts down when you’re head
over heels, masking your fear. This explains why couples are more adventurous when trying
to impress their new partner, doing things they normally wouldn’t do, or making decisions
they normally wouldn’t make. Las Vegas impulse weddings are the first thing that comes to
mind, followed by first dates that include daredevil activities such as skydiving or tattooing
your significant others name to various body parts. It is in the brain’s best interest not to
remain in this state for too long, if only for self-preservation.
Love at First Sight… Fact or Fiction?

In a study conducted by Dr. Helen Fisher, PhD, only 11% of couples polled said they had
found love at first sight. With the rush of chemicals, and high levels of brain activity, it
is possible to see why couples would feel as if it was instantaneous, soul-mate level love.
Especially if their relationship started out during an exciting event or time in their lives, as an
adrenaline rush can create a bond between people. And although I am not ruling out that
magical, cosmic possibility, it’s best advised that couples take the time to really get to know
one another, to bond over similarities in life goals, their character traits and their priorities,
more so than basing their relationship future solely on fleeting chemical reactions.

Runway Magazine Editorial Team
Runway Magazine Editorial Teamhttps://runwaylive.com
Freelance articles written by the editors of Runway Magazine. With over 200 years of combined experience covering luxury fashion, beauty, high-end lifestyle, and pop culture, our team delivers authoritative, insightful commentary on the trends shaping 2026. Every piece is crafted by seasoned fashion and lifestyle editors who prioritize depth, cultural context, and forward-looking analysis.

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